Publications / Bibliography

Cheng Y and Ho MS#, 2025, Disease-associated microglia in neurodegenerative diseases, invited Essay, PLOS Biol. 2025 Oct 21;23(10):e3003426

Wang H, Wang M, Tsai Y, Cheng Y, Lin Y, Lin C, Lee Y, Wang L, Yi S, Zhang S, Pan Y#, Ho MS#, 2025, VAMP7-dependent mitochondria-lysosome contacts regulate glial mitochondrial dynamics and dopaminergic neuron survival, bioRxiv, Aug 17, 2021, 2021.08.16.456582 (under review, Nature Communications). 

Wang L, Yi S, Zhang S, Tsai Y, Cheng Y, Lin Y, Lin C, Lee Y, Wang H, Ho MS#, 2025, New Atg9 phosphorylation sites regulate autophagic trafficking in glia, ASN Neuro, 17(1):2443442.

Zhang S, Wang L, Yi S, Tsai Y, Cheng Y, Lin Y, Lin C, Lee Y, Wang H, Li S, Wang R, Liu Y, Yan W, Liu C, He K, Ho MS#, 2025, Drosophila aux orchestrates the phosphorylation dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation, Autophagy, Jan 29:1-20 (featured in TVBS新聞/over 140K views、台視發現科學新聞/over 100K views、遠見雜誌專欄/over 50K views、環球生技月刊、陽明交大114年第一季重要期刊論文).

Li T, Shi W, Ho MS#, Zhang YQ#, 2024, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife, Version of Record, 10.7554/eLife.87258.2 (featured in Brainnews public forum). 

Wang L, Zhang S, Yi S, Ho MS#, 2023, A new regulator of autophagy initiation in glia, Autophagy, Aug 29;1-3, invited commentary. 

Wang M and Ho MS#, 2023, Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis, Front. Neural Circuits 17:1252759.

Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS#, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci U S A, Jul 18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED public forums).

Yi S, Wang L, Ho MS, Zhang S#, 2023, The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson's disease, Neural Regen Res, 19(5):1150-1155.

Wang L, Wang H, Yi S, Zhang S, Ho MS#, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic, Oct;23(10):506-520 (featured on the Cover). 

Yang M, Wang H, Chen C, Zhang S, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS#, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci U S A, 118(23):e2020098118 (featured in Logical Thinking Neuroscience public forum).

Yang M, Guo Y, Wang S, Chen C, Chang YH, Ho MS#, 2021, The F-Box protein CG5003 regulates axon pruning and the integrity of the Drosophila mushroom body, Front Mol Neurosci, 14:634784.

Liu YJ#, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD#, Ho MS#, Duan S, 2021, The noncanonical role of the protease cathepsin D as a cofilin phosphatase, Cell Res, 31(7):801-813 (last corresponding author).

Cheng J, Wang H, Bartlett M, Stevenson D, Pan Y, Ho MS#, Ren Y#, 2021, Antioxidant blend of curcumin and broccoli seed extract exhibits protective effect on neurodegeneration and promotes Drosophila lifespan, ASN Neuro, 13:17590914211015033.

Liu YJ, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS#, Wang XD#, Duan S#, 2020, Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD, Sci Adv, 6(50):eaba5783.

Hao X, Wang S, Lu Y, Yu W, Li P, Jiang D, Guo T, Li M, Li J, Xu J, Wu W, Ho MS#, Zhang L#, 2020, Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling, eLife, 9:e47542.

Li M, Hu X, Zhang S, Ho MS, Wu G, Zhang L, 2019, Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila, Sci Rep, 9(1):10124.

Zhang S, Guo X, Wu H, Sun Y, Ma X, Li J, Xu Q, Wu C, Li Q, Jiang C, Li W, Ho MS, Lv Z, Xue L, 2019, Wingless modulates activator protein-1-mediated tumor invasion, Oncogene, 38(20):3871-3885. 

Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, Ma X, He L, Wu W, Yin M, Ge L, Wang Z, Ho MS, Zhao Y, Fei Z, Zhang L, 2018, The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex, J Biol Chem, 293(44):17119-17134.

Cao W, Song L, Cheng J, Yi N, Cai L, Huang FD, Ho MS#, 2017, An automated rapid iterative negative geotaxis assay for analyzing adult climbing behavior in a Drosophila model of neurodegeneration, J Vis Exp, (127):56507.

Xiao X, Chen C, Yu TM, Ou J, Rui M, Zhai Y, He Y, Xue L, Ho MS#, 2017, Molecular chaperone Calnexin regulates the function of Drosophila sodium channel Paralytic, Front Mol Neurosci, 10:57.

Chen C, Yin S, Cao W, Ho MS#, 2017, Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia, J Genet Genomics, 44(1):67-70.

Xi X, Lu L, Zhuge CC, Chen X, Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS#, 2017, The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation, Sci Rep, 7:39856.

Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS#, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Cell Rep, 18(5):1132-1143.

Xu J, Hao X, Yin MX, Lu Y, Jin Y, Xu J, Ge L, Wu W, Ho MS, Yang Y, Zhao Y, Zhang L, 2017, Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity, Development, 144(8):1510-1517.

Ou J, Gao Z, Song L, Ho MS#, 2016, Analysis of glial distribution in Drosophila adult brains, Neurosci Bull, 32(2):162-70. 

Hu L, Xu J, Yin MX, Zhang L, Lu Y, Wu W, Xue Z, Ho MS, Gao G, Zhao Y, Zhang L, 2016, Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded, Cell Discov, 2:15047.

Wang C, Zhang W, Yin MX, Hu L, Li P, Xu J, Huang H, Wang S, Lu Y, Wu W, Ho MS, Li L, Zhao Y, Zhang L, 2015, Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis, Nat Commun, 6:6607.

Wang X, Wang Z, Chen Y, Huang X, Hu Y, Zhang R, Ho MS, Xue L, 2014, FoxO mediates APP-induced AICD-dependent cell death, Cell Death Dis, 5(5):e1233.

Chen J, Yan H, Ren DN, Yin Y, Li Z, He Q, Wo D, Ho MS, Chen Y, Liu Z, Yang J, Liu S, Zhu W, 2014, LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation, Cellular Signaling, 26(5):1068-74.

Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z, Duan S, 2014, Analysis of microglial migration by a micropipette assay, Nat Protoc, 9(2):491-500.

Jin Y, Xu J, Yin MX, Lu Y, Hu L, Li P, Zhang P, Yuan Z, Ho MS, Ji H, Zhao Y, Zhang L, 2013, Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling, eLife, 2:e00999.

Wu JT, Lin WH, Chen WY, Huang YC, Tang CY, Ho MS, Pi H, Chien CT, 2011, CSN-mediated deneddylation differentially modulates Ci (155) proteolysis to promote Hedgehog signalling responses, Nat Commun, 2:182.

Ho MS*, Chen H, Chen M, Jacques C, Giangrande A, Chien CT, 2009, Gcm protein degradation suppresses proliferation of glial progenitors, Proc Natl Acad Sci U S A, 106(16):6778-83 (This article won the France-Taiwan Scientific Prize and was featured in the Asia-Pacific International Molecular Biology Network A-IMBN)  

Ho MS*, Carniol K, Losick R, 2003, Evidence in support of a docking model for the release of the transcription factor sigma F from the antisigma factor SpoIIAB in Bacillus subtilis, J Biol Chem, 278(23):20898-905.