Principal Investigator
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E-mail: margaret.ho@nycu.edu.tw
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TEL (Office): +886-2-2826-7998
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TEL (Lab): +886-2-2826-6099
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CV: ORCID
Education
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2003 Ph.D., Department of Molecular and Cellular Biology Harvard University, USA
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1999 Bachelor of Arts, Department of Molecular and Cellular Biology, Biochemistry University of California at Berkeley, USA
Career
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2026 - present Professor, Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei
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2024 - 2026 Associate Professor, Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei
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2017 - 2024 Associate Professor, School of Life Sciences and Technology, ShanghaiTech University, Shanghai (tenured 2022.05)
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2010 - 2017 Distinguished Professor, School of Medicine, Tongji University, Shanghai
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2003 - 2010 Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taipei
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1998 - 1999 Research Assistant, Department of Chemistry and Chemical Biology, Harvard University, Cambridge
Honor
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國科會 112 年度 2030 跨世代國際年輕傑出學者
Representative Publications
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Cheng Y and Ho MS#, 2025, Disease-associated microglia in neurodegenerative diseases, invited Essay, PLOS Biol. 2025 Oct 21;23(10):e3003426
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Zhang S, Wang L, Yi S, Tsai Y, Cheng Y, Lin Y, Lin C, Lee Y, Wang H, Li S, Wang R, Liu Y, Yan W, Liu C, He K, Ho MS#, 2025, Drosophila aux orchestrates the phosphorylation dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation, Autophagy. Jan 29:1-20 (Featured in TVBS News (over 140,000 views), TTV Discover Science News (over 100,000 views), Global Views Magazine (column; over 50,000 views), Global Bio & Investment Monthly, and NYCU Highlights: Major Journal Publications, Q1 2025).
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Li T, Shi W, Ho MS#, Zhang YQ#, 2024, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife. Version of Record, 10.7554/eLife.87258.2 (featured in Brainnews public forum).
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Wang L, Zhang S, Yi S, Ho MS#, 2023, A new regulator of autophagy initiation in glia, Autophagy. Aug 29;1-3, invited commentary.
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Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS#, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci U S A. Jul 18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED public forums).
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Wang L, Wang H, Yi S, Zhang S, Ho MS#, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic. Oct;23(10):506-520 (featured on the Cover).
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Yang M, Wang H, Chen C, Zhang S, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS#, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci U S A. 118(23):e2020098118 (featured in Logical Thinking Neuroscience public forum).
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Liu YJ*, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS#, Duan S, 2021, The noncanonical role of the protease cathepsin D as a cofilin phosphatase, Cell Res. 31(7):801-813 (last corresponding author).
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Liu YJ, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS#, Wang XD*, Duan S*, 2020, Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD, Sci Adv. 6(50):eaba5783.
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Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS#, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Cell Rep. 18(5):1132-1143.