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實驗室主持人

何淑君 教授.jpg

學歷

  • 美國哈佛大學 分子細胞生物學 博士(2003

  • 美國加州大學 柏克萊分校 分子與細胞生物學暨生物化學 學士(1999

Education

​經歷

  • 國立陽明交通大學 神經科學研究所 教授(2026 至今)

  • 國立陽明交通大學 神經科學研究所 副教授(2024 - 2026

  • 上海科技大學 生命科學與技術學院 副教授(2017 – 2024, 20225月取得終身職)

  • 上海同濟大學醫學院 特聘教授(2010 – 2017

  • 中央研究院 分子生物研究所 博士後研究員(2003 – 2010

  • 哈佛大學 化學與化學生物學系 研究助理(1998 – 1999

Career

榮譽

  • 國科會 112 年度 2030 跨世代國際年輕傑出學者 

Honor
Representative Publications

代表著作

  1. Cheng Y and Ho MS#, 2025, Disease-associated microglia in neurodegenerative diseases, invited Essay, PLOS Biol. 2025 Oct 21;23(10):e3003426

  2. ​Zhang S, Wang L, Yi S, Tsai Y, Cheng Y, Lin Y, Lin C, Lee Y, Wang H, Li S, Wang R, Liu Y, Yan W, Liu C, He K, Ho MS#, 2025, Drosophila aux orchestrates the phosphorylation dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation, Autophagy. Jan 29:1-20 (Featured in TVBS News (over 140,000 views), TTV Discover Science News (over 100,000 views), Global Views Magazine (column; over 50,000 views), Global Bio & Investment Monthly, and NYCU Highlights: Major Journal Publications, Q1 2025).

  3. Li T, Shi W, Ho MS#, Zhang YQ#, 2024, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife. Version of Record, 10.7554/eLife.87258.2 (featured in Brainnews public forum).

  4. Wang L, Zhang S, Yi S, Ho MS#, 2023, A new regulator of autophagy initiation in glia, Autophagy. Aug 29;1-3, invited commentary.

  5. Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS#, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci U S A. Jul 18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED public forums).

  6. Wang L, Wang H, Yi S, Zhang S, Ho MS#, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic. Oct;23(10):506-520 (featured on the Cover).

  7. Yang M, Wang H, Chen C, Zhang S, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS#, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci U S A. 118(23):e2020098118 (featured in Logical Thinking Neuroscience public forum).

  8. Liu YJ*, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS#, Duan S, 2021, The noncanonical role of the protease cathepsin D as a cofilin phosphatase, Cell Res. 31(7):801-813 (last corresponding author).

  9. Liu YJ, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS#, Wang XD*, Duan S*, 2020, Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD, Sci Adv. 6(50):eaba5783.

  10. Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS#, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Cell Rep. 18(5):1132-1143.

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 聯絡我們

  • Dr. Margaret S. Ho

  • 信箱: margaret.ho@nycu.edu.tw

  • 地址:112 台北市北投區立農街二段 155 號圖書資訊大樓 419

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